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Watch Carefully (1)istradefylline will boost the amount or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism.diazepam increases amounts of lomitapide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose must not exceed 30 mg/day.Paradoxical reactions might manifest such as hall